| Publications
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| Articles |
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A Role for Ubiquitin in
the Spliceosome Assembly Pathway |
| U2 toggles
iteratively between the stem IIa and stem IIc conformations to promote
pre-mRNA splicing Hilliker, A.K., Mefford, M A. & Staley, J.P. Genes Dev 2007, 21(7):821-834. [Abstract] [Full Text] |
| DEAD on Mayas, R.M. & Staley, J.P. Nature Struct Mol Biol 2006, 13:954-955. [Full Text] |
|
The EF-G-like GTPase Snu114
Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H-box ATPase |
| Exon ligation
is proofread by the DExD/H-box ATPase Prp22p Mayas, R.M., Maita, H. and Staley, J. P. Nature Struct Mol Biol 2006, 13:482-490. [Abstract] [Full Text] [News and Views] |
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The splicing factor Prp43p,
a DEAH box ATPase, functions in ribosome biogenesis |
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Multiple functions for
the invariant AGC triad of U6 snRNA |
| Hanging on to the branch
Staley, J. P. Nat Struct Biol 2002, 9:5-7. [Full Text] |
| Specific alterations of
U1-C protein or U1 small nuclear RNA can eliminate the requirement of
Prp28p, an essential DEAD box splicing factor. Chen, J. Y.-F., Stands, L. Staley, J. P., Jackups, R. R., Jr. and Chang, T. -H. Molecular Cell 2001, 7:227. [Abstract] [Full Text] Reviewed in Nature Structural Biology, Vol. 8, No. 2, 113-116, February, 2001. |
| An RNA switch at the 5'
splice site requires ATP and the DEAD box protein Prp28p.
Staley, J. P. & Guthrie, C. Molecular Cell 1999, 3:55-64. [Abstract] [Full Text] Reviewed in Cell, Vol. 96, 599Ð602, March, 1999. |
| Mechanical devices of the
spliceosome: motors, clocks, springs and things. Staley, J. P. & Guthrie, C. Cell 1998, 92:315-326. [Abstract] [Full Text] |
| Formation of a native-like
subdomain in a partially folded intermediate of bovine pancreatic trypsin
inhibitor. Staley, J. P. & Kim, P. S. Protein Science 1994, 3:1822-1832. [Abstract] |
| Complete folding of bovine
pancreatic trypsin inhibitor with only a single disulfide bond.
Staley, J. P. & Kim, P. S. Proc. Natl. Acad. Sci. USA 1992, 89:1519-1523. [Abstract] [Full Text] |
| Role of a subdomain in
the folding of bovine pancreatic trypsin inhibitor. Staley, J. P. & Kim, P. S. Nature 1990, 344:685-688. [Abstract] |
| Recent Meeting Presentations |
| A Genetic Analysis
Of The Proofreading Activity Of Prp22 Alissa Anderson, Prakash Koodathingal, Melissa Mefford, Jonathan Staley 12th Annual Meeting of the RNA Society (2007) [Abstract] |
| Ubiquitin Regulates Brr2p-dependent
Spliceosome Dynamics Eliza Small, Priya Bellare, Erik Sontheimer, Jonathan Staley 12th Annual Meeting of the RNA Society (2007) [Abstract] |
| Establishing pre-mRNA splicing
fidelity: a common ATP-dependent mechanism for 5' and 3' splice site cleavage? P Koodathingal, H Maita, R Mayas, T Novak, J Piccirilli, J Staley 12th Annual Meeting of the RNA Society (2007) [Abstract] |
| Genome-wide analysis of
intron function in yeast Alejandro Montenegro-Montero, Alex Plocik, Rich Wang, Christine Guthrie, Jonathan Staley 12th Annual Meeting of the RNA Society (2007) [Abstract] |
| A common ATP-depenent framework
for establishing pre-mRNA splicing fidelity during 5' and 3' splice site
cleavage Prakash Koodathingal, Hiroshi Maita, Rabiah Mayas, Thad Novak, Joseph Piccirilli, Jonathan Staley Eukaryotic mRNA Processing, Cold Spring Harbor (2007) |
| U2/U6 helix I promotes
both catalytic steps of splicing and the DExD/H-box ATPase Prp16 promotes
U2/U6 helix I dynamics Melissa Mefford, Jonathan Staley Eukaryotic mRNA Processing, Cold Spring Harbor (2007) |
| Investigating a role for
spliceosome disassembly factors in discard of aberrant splicing substrates
Rabiah Mayas, Hiroshi Maita, Jonathan Staley Eukaryotic mRNA Processing, Cold Spring Harbor (2007) |